His departure comes as Donald Trump ordered a withdrawal of US forces from Syria and suggestions he'll pull thousands out of Afghanistan too.
In his resignation letter, Mattis said he believes in treating allies with respect. Trump’s announcement certainly took the US's friends by surprise and left many wondering if the US is a dependable ally.
So with Mattis gone, who will now try and control an unpredictable president?
Presenter: Imran Khan | Guests: David DesRoches, Professor of Near East South Asia Center for Strategic Studies at the National Defense University and Former Director of NATO Operations at the Pentagon; Habib Wardak, Founding Member of Transparency Afghanistan and National Security Analyst; Andreas Krieg, Assistant Professor at the Defence Studies Dept., King's College London and Specialist on Jihadist Groups in the Middle East.