The 60-year-old was found guilty on five of the six counts she faced - including the most serious charge, that of sex trafficking a minor.
The verdict was reached after five full days of deliberation by a 12-person jury in New York.
It means the British socialite could spend the rest of her life behind bars.
The verdict followed a month-long trial that featured testimony from four women who described being abused by Epstein between 1994 and 2004.
Reeta Chakrabarti presents BBC News at Ten reporting by Aleem Maqbool.
