Government forecasters have warned of severe thunderstorms from the Gulf of Mexico up to the Great Lakes.
On Sunday and Monday, tornadoes cut a broad track of death and destruction through the southern US states.
The storms flattened buildings, overturned cars, and left thousands of residents without power.
"Widespread thunderstorms are forecast across the central Gulf Coast region, with several severe [or] supercell storms possible," the National Weather Service wrote in a morning forecast.
More than two million people are said to be at risk of tornadoes and high winds in parts of Alabama and Mississippi on Tuesday.
As the storm moves further east, parts of Florida, Georgia, North Carolina and South Carolina are expected to be under threat of severe weather, forecasters say. (+ BBC videos) » | Tuesday, April 29, 2014