Republican James Comer, chairman of the House Oversight Committee, issued the subpoenas to the Clintons and eight other individuals.
The committee is seeking information about Epstein's history, after President Donald Trump's administration decided against releasing more federal files on the dead financier.
That decision sparked outrage among Trump supporters and some Democrats, who refused to accept the justice department's statement that there was no "incriminating client list" in the Epstein files.