Walid Muallem said Syria was "the centre of the international coalition to fight Islamic State".
The US has already bombed IS fighters in Iraq and has hinted it would be willing to take action in Syria.
Western powers generally shun Syria's government, accusing it of carrying out atrocities in its three-year civil war.
But Mr Muallem warned that the US must co-ordinate with the Syrian government before launching any air strikes on its territory.
"Anything outside this is considered aggression," he said. (+ BBC video) » | Monday, August 25, 2014
